Diabetes mellitus remains a significant worldwide health concern, demanding the development of more efficient, patient-friendly treatment approaches. By increasing drug absorption and enhancing patient compliance while reducing systemic side effects, an alternative to oral and injectable drugs that is non-invasive is provided by transdermal drug delivery systems. Current developments in the production of antidiabetic transdermal patches employing natural bioactive substances extracted from therapeutic plants are examined in this review. The molecular functions of phytochemicals, including polyphenols, alkaloids, and terpenoids, in glycemic control are highlighted, as is the development of patch designs using both traditional and cuttingedge fabrication methods, such as microneedles, electrospinning, and 3D printing. Additionally, the potential of smart technologies and nanocarrier systems, like liposomes, phytosomes, and ethosomes, integrated into patch matrices to enhance medication delivery and therapeutic results is emphasized. Recent patents and experimental prototypes demonstrate the translational significance of these inventions. The synergistic potential of enhanced TDDS and natural bioactives in revolutionizing diabetic care is thoroughly examined in this research, which also calls for additional clinical validation and interdisciplinary cooperation.
Dua et al. (Tue,) studied this question.