Digital twin (DT) technologies are increasingly applied in manufacturing to support monitoring, optimization, and predictive maintenance; however, most implementations remain operationally focused and disconnected from system-level decision-making and lifecycle engineering. This limitation is particularly critical in manufacturing environments that exhibit System-of-Systems (SoS) characteristics, where performance emerges from the interactions among autonomous, interdependent subsystems. This study proposes an integrated systems engineering framework in which the digital twin functions as a system-level integrator rather than a standalone simulation tool. The framework embeds Quality Function Deployment (QFD), Analytic Hierarchy Process (AHP), Reliability and Safety analysis (RAMST), and Statistical Process Control (SPC) within a unified digital twin architecture, enabling explicit traceability from stakeholder requirements to design decisions, operational control, and lifecycle performance. The framework is demonstrated through a robotic fastening system operating under high variability, multi-vendor integration, and reliability constraints. A high-fidelity digital twin was developed in MATLAB Simscape and synchronized with operational data via virtual sensors and SPC-based monitoring. Results from a 35-month simulation study (n = 1050 operations) show a 30% reduction in system downtime and a 15% improvement in fastening quality (torque and angle compliance), supported by 95% confidence intervals, alongside enhanced fault detection and preventive maintenance capabilities. The findings demonstrate that integrating decision-making, monitoring, and learning within a single DT environment supports resilient, adaptive manufacturing systems aligned with Industry 4.0–5.0 objectives.
Levi et al. (Tue,) studied this question.