Cell Therapy Manufacturing at Full Clinical Scale: Enhancing the Quality CAR-T Cell Therapy Starting Materials Through Massively Parallel Automated Microfluidic Cell Sorting

Key Points

• The research aims to enhance the quality of CAR-T cell therapy starting materials via automated microfluidic cell sorting.
• Developed a massively parallel automated microfluidic system for cell sorting
• Focused on the production process of autologous CAR-T cells
• Evaluated the impact of sorting on cell quality
• Significant improvements in the homogeneity of CAR-T cells post-sorting
• Increased yield of high-quality starting materials
• Achieved a more streamlined manufacturing process