Cell Therapy Manufacturing at Full Clinical Scale: Enhancing the Quality CAR-T Cell Therapy Starting Materials Through Massively Parallel Automated Microfluidic Cell Sorting

Alison Skelley; Yasna Behmardi; Luke Peterson; David Inglis; Mabel Shehada; Laurissa Ouaguia; Khushroo Gandhi; Roberto Campos-González; Tony Ward

doi:10.1039/d6lc00072j

January 1, 2026Lab on a ChipOpen Access

Cell Therapy Manufacturing at Full Clinical Scale: Enhancing the Quality CAR-T Cell Therapy Starting Materials Through Massively Parallel Automated Microfluidic Cell Sorting

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Key Points

The research aims to enhance the quality of CAR-T cell therapy starting materials via automated microfluidic cell sorting.
Developed a massively parallel automated microfluidic system for cell sorting
Focused on the production process of autologous CAR-T cells
Evaluated the impact of sorting on cell quality
Significant improvements in the homogeneity of CAR-T cells post-sorting
Increased yield of high-quality starting materials
Achieved a more streamlined manufacturing process

Implication

Demonstrates improved quality of CAR-T cell therapy materials in hematologic malignancies, suggesting better manufacturing processes.

Abstract

Autologous CAR-T cell therapy has demonstrated remarkable clinical efficacy in hematologic malignancies, yet its broader application remains limited by complex, labor-intensive manufacturing and inconsistent product quality. We describe a novel...

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Cite This Study

Skelley et al. (2026) studied this question.

synapsesocial.com/papers/69cf5f505a333a821460e738 https://doi.org/10.1039/d6lc00072j

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Cell Therapy Manufacturing at Full Clinical Scale: Enhancing the Quality CAR-T Cell Therapy Starting Materials Through Massively Parallel Automated Microfluidic Cell Sorting

Key Points

Implication

Abstract

Discussion

Cite This Study

Cell Therapy Manufacturing at Full Clinical Scale: Enhancing the Quality CAR-T Cell Therapy Starting Materials Through Massively Parallel Automated Microfluidic Cell Sorting

Key Points

Implication

Abstract

Discussion

Cite This Study

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