Existing biology shows the path to biological immortality

This preprint argues that complementary single-strand lesions (CSSLs) are the primary irreversible form of nuclear DNA damage driving aging. A simple Bayesian model, built on literature values for daily new damage (~70,000 lesions/cell) and steady-state damage (~38,000 lesions/cell), quantitatively reproduces the observed human lifespan (~76 years). It then introduces the Artificial Biological Immortality System (ABIS): a novel synthetic system that maintains permanent “sisterized” chromatids throughout the entire cell cycle, enabling continuous high-fidelity DNA repair via sister chromatid exchange. ABIS is engineered from existing biological components (replisome-coupled deposition of alternating orthogonal sets of MEIKIN/cohesin plus separase) and is designed to be directly testable in mammalian cells. Because DNA damage is not the sole driver of aging and functional decay over time, complementary solutions are also proposed for polymerase fidelity, nucleotide repeat instability, mitotic segregation errors, cancer, senescence, bioaccumulation, tissue overgrowth, and regeneration.