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April 12, 2026JAMA Network Open0 citationsOpen Access

Risk Prediction Model for Taxane-Induced Peripheral Neuropathy in Early-Stage Cancer

MTMeghna Trivedi JUJoseph M. Unger NHN. Lynn Henry

Key Points

The aim is to develop a risk prediction model for taxane-induced peripheral neuropathy (TIPN) in patients with early-stage cancer.
Cohort study design involving participants with early-stage cancer
Assessment of baseline risk factors associated with TIPN
Development of a risk prediction model based on identified factors
Identification of significant baseline risk factors for TIPN
Creation of a predictive model to estimate TIPN risk
Potential for guiding treatment decisions and monitoring symptoms

Abstract

In this cohort study of participants with early-stage cancer receiving a taxane regimen, a set of baseline risk factors stratified TIPN risk. A risk prediction model may guide treatment decision-making, symptom monitoring, and enrollment in interventional trials for TIPN prevention and treatment.

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