1,5-Regioselectivity in 1,2,3-Triazole from Metal Catalyzed Azide-Alkyne Cycloaddition: Synthetic Strategies and Catalytic Scopes

Key Points

• This research aims to explore the regioselectivity of 1,2,3-triazole synthesis via metal-catalyzed methods.
• Utilized copper(I)-catalyzed azide-alkyne cycloaddition for synthesis.
• Investigated various synthetic strategies for improved selectivity.
• Analyzed different catalytic scopes and conditions.
• Identified effective synthetic routes for regioselective 1,5-disubstitution.
• Demonstrated significant improvements in yield and selectivity.
• Highlighted potential applications in pharmaceuticals and materials science.