1,5-Regioselectivity in 1,2,3-Triazole from Metal Catalyzed Azide-Alkyne Cycloaddition: Synthetic Strategies and Catalytic Scopes

Kunj B. Mishra; Priyanka Chaudhary; Yogendra Kumar; Utkarsh Sharma; Adesh Kumar Singh; Priyanka Parashar; Vishal Goswami

doi:10.1039/d5cy01607j

January 1, 2026Catalysis Science & Technology

1,5-Regioselectivity in 1,2,3-Triazole from Metal Catalyzed Azide-Alkyne Cycloaddition: Synthetic Strategies and Catalytic Scopes

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to explore the regioselectivity of 1,2,3-triazole synthesis via metal-catalyzed methods.
Utilized copper(I)-catalyzed azide-alkyne cycloaddition for synthesis.
Investigated various synthetic strategies for improved selectivity.
Analyzed different catalytic scopes and conditions.
Identified effective synthetic routes for regioselective 1,5-disubstitution.
Demonstrated significant improvements in yield and selectivity.
Highlighted potential applications in pharmaceuticals and materials science.

Implication

Synthetic strategies achieve regioselectivity in 1,2,3-triazoles, suggesting broader applications in chemistry.

Abstract

1,2,3-Triazoles constitute a prominent class of nitrogen-rich heterocycles with remarkable chemical stability and wide-ranging applications. Since the arrival of copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), the facile synthesis of 1,4-disubstituted 1,2,3-triazoles has...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Mishra et al. (2026) studied this question.

synapsesocial.com/papers/69db38534fe01fead37c68d3 https://doi.org/10.1039/d5cy01607j

View Full Paper

Ask AI

Bookmark

Share

1,5-Regioselectivity in 1,2,3-Triazole from Metal Catalyzed Azide-Alkyne Cycloaddition: Synthetic Strategies and Catalytic Scopes

Key Points

Implication

Abstract

Discussion

Cite This Study

1,5-Regioselectivity in 1,2,3-Triazole from Metal Catalyzed Azide-Alkyne Cycloaddition: Synthetic Strategies and Catalytic Scopes

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading