What question did this study set out to answer?

To identify clinical and inflammatory predictors of post-procedural exacerbations in patients undergoing BLVR with EBVs.

April 24, 2026Open Access

Understanding exacerbation risk in BLVR: A logistic regression approach to complication prediction

Key Points

To identify clinical and inflammatory predictors of post-procedural exacerbations in patients undergoing BLVR with EBVs.
Retrospective analysis of 320 patients with advanced emphysema treated with EBVs from 2015 to 2022.
Comprehensive preprocedural evaluations included pulmonary function tests and imaging.
Binary logistic regression was applied to find independent predictors of exacerbations.
10.9% of patients experienced post-BLVR exacerbations, with six cases of pneumonia.
Significant predictors included diabetes mellitus type II and elevated C-reactive protein.
The logistic regression model showed excellent discriminative ability (AUC = 0.923).

Abstract

Background Chronic obstructive pulmonary disease (COPD) with emphysema is associated with persistent airflow limitation and frequent exacerbations. Bronchoscopic lung volume reduction (BLVR) with endobronchial valves (EBVs) improves lung function and quality of life but carries a risk of postprocedural complications, including acute exacerbations and pneumonia. Predictors of these adverse events remain incompletely defined. Purpose To identify clinical and inflammatory factors associated with postprocedural exacerbations in patients undergoing BLVR with EBVs, aiming to support individualized risk stratification. Patients and Methods We retrospectively analyzed 320 patients with advanced emphysema treated with EBVs between 2015 and 2022. Patients underwent comprehensive preprocedural evaluation, including pulmonary function testing, imaging, perfusion scintigraphy, 6-minute walk test and COPD Assessment Test. Postprocedural exacerbations within 8 weeks were documented clinically and radiographically. Binary logistic regression, including multivariable modeling, was used to identify independent predictors. Results Thirty-five patients (10.9%) developed post-BLVR exacerbations, six of whom had pneumonia. Exacerbation risk was independently associated with diabetes mellitus type II (OR 11.0, p 1 mg/dL (OR 9.35, p 11 cells/nL (OR 5.46, p = 0.002), prior exacerbation frequency (OR 2.94, p < 0.001) and low BMI (OR 0.78, p < 0.001). Residual volume showed a trend toward significance ( p = 0.058). The final model demonstrated excellent discriminative ability (AUC = 0.923). While lung function improvement was attenuated in the exacerbation group, quality of life gains were comparable. Conclusion Elevated inflammatory markers, diabetes, frequent prior exacerbations and low BMI were independently associated with early postprocedural exacerbations following BLVR with EBVs. Comprehensive preprocedural assessment and targeted management of these risk factors may enhance patient safety and improve outcomes.

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