Purpose: Recent reviews on lateral epicondylitis management frequently focus on single modalities or isolated outcomes. This study systematically evaluates the time-dependent efficacy and safety of eight percutaneous treatments (placebo, corticosteroids, platelet-rich plasma PRP, autologous blood AB, hyaluronic acid, botulinum toxin BT, dextrose prolotherapy DPT, and dry needling DN) for lateral epicondylitis. Patients and Methods: Four databases (PubMed, Embase, the Cochrane Library, and Web of Science) were searched for randomized controlled trials. Outcomes (pain intensity, functional disability, grip strength) were evaluated across short- ( 6 months) intervals. Data were synthesized via network meta-analysis using mean differences (MD) or standardized mean differences (SMD) and SUCRA probabilities. Results: Forty-one trials (N=3,285) were included. Corticosteroids showed substantial efficacy for short-term pain relief (MD − 1.62, 95% CI − 2.52 to − 0.72) but were associated with a long-term rebound effect. DPT demonstrated notable advantages for mid-term pain reduction (MD − 1.73, 95% CI − 2.85 to − 0.60) and functional recovery. BT was associated with a potential negative trend in mid-term grip strength compared to placebo, whereas AB showed better outcomes than BT in head-to-head comparisons. For long-term outcomes, regenerative approaches like PRP, along with DN and BT, appeared to provide sustained pain relief. Conclusion: The therapeutic efficacy of percutaneous treatments appears to be time-dependent. Corticosteroids may be considered for rapid short-term relief, while DPT shows potential advantages for mid-term recovery. For long-term management, PRP and DN may offer sustained analgesia, potentially avoiding the grip strength deficits occasionally associated with BT. Plain Language Summary: Tennis elbow (lateral epicondylitis) is a common condition that causes pain on the outside of the elbow, making it difficult to grip objects or use your arm. Many different injection therapies and needling techniques are available, but patients and doctors often wonder which one works best and when. To answer this, we combined the results of 41 clinical trials involving 3285 patients. We compared eight common treatments (including steroid injections, platelet-rich plasma, dextrose prolotherapy, and dry needling) to see how well they reduced pain and improved grip strength over three timeframes: short-term (under a month), mid-term (one to three months), and long-term (over six months). We found that no single treatment is universally superior across all stages of recovery. Instead, the best choice depends on how long the patient has been healing. For immediate pain relief in the first few weeks, steroid injections worked the fastest, but their effects often wore off later. For recovery between one and three months, dextrose prolotherapy was the most effective option for reducing pain and improving daily function. When looking at long-term results (over six months), treatments like platelet-rich plasma and dry needling provided lasting pain relief. Importantly, we noticed that while botulinum toxin also reduced pain, it showed a concerning trend of weakening patients’ grip strength compared to other therapies like autologous blood injections. In short, this study helps doctors tailor treatments to a patient’s specific healing stage, offering a clear roadmap for managing tennis elbow safely and effectively over time. Keywords: tennis elbow, platelet-rich plasma, dry needling, dextrose prolotherapy, grip strength, pain management
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