What question did this study set out to answer?

This research focuses on the mass spectral analysis of a specific isoquinolinium salt and its differentiation from other alkaloids.

April 30, 2026Open Access

Electron ionisation mass spectral study of 2-(2-carboxy-4, 5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt

Key Points

This research focuses on the mass spectral analysis of a specific isoquinolinium salt and its differentiation from other alkaloids.
Analyzed electron ionization mass spectrum of isoquinolinium inner salt
Proposed fragmentation routes for molecular ion
Compared with EI-MS data of various alkaloids
Identified unique fragmentation patterns for the isoquinolinium salt
Differentiated it from metameric protopine alkaloids
Provided data useful for metabolite identification in biological samples

Abstract

The electron ionization mass spectrum of 2-(2-carboxy-4,5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt 1 is discussed and general fragmentation routes of its molecular ion are proposed. Comparison of the data obtained for 1 with the EI-MS data of metameric protopine alkaloids (allocryptopine, argemexicaine A, argemexicaine B) and the pseudobenzyloisoquinoline alkaloid taxilamine allows a differentiation between these metamers. The data will be useful for the identification of metabolites of alkaloids of these types in biological matrices.

Electron ionisation mass spectral study of 2-(2-carboxy-4, 5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt

Key Points

Abstract

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