Influence of Base Excision Repair Gene hOGG1, XRCC1, and APE1 Polymorphisms on Renal Cell Carcinoma Susceptibility and Progression

Objective: This study aimed to explore whether polymorphisms in hOGG1, XRCC1, and APE1 genes influenced the initiation and progression of renal cell carcinoma (RCC) and to investigate the relationship between polymorphisms of the three base excision repair (BER) genes and cigarette smoking among RCC patients.Materials and Methods: This study involved 211 controls and 97 patients. The polymorphisms of DNA repair genes hOGG1 Ser326Cys, XRCC1 Arg399Gln, and APE1 Asp148Glu were explored using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results: Our results showed no significant association between hOGG1 Ser326Cys polymorphism and RCC risk. There was a statistically significant association between the XRCC1 399 Gln allele and the APE1 148 Glu allele and RCC risk. In addition, the XRCC1 399 Gln allele significantly increased the initiation of RCC when accompanied by smoking status. The variant genotypes of hOGG1, XRCC1, and APE1 showed no significant association with RCC progression.Conclusion: Our findings suggest that XRCC1 and APE1 gene polymorphisms that contribute to BER pathway may regulate RCC susceptibility in a Turkish population.