Siddha Therapeutic Approaches in the Management of Cervical Cancer: A Review of Classical Formulations and Their Pharmacological Relevance

Cervical cancer ranks as the second most common cancer among women in India, with an estimation of 1.23 to 1.27 lakh new cases reported annually, posing a significant health burden to the country. In Siddha system of medicine, conditions analogous to cervical malignancies are described under the term “Yoni Puttru”. The present review aims to systematically compile Siddha herbal, herbo – mineral and mineral formulations indicated for Yoni Puttru from classical siddha texts listed in the First Schedule of the Drugs and Cosmetics Act, 1940 and to explore their potential pharmacological relevance. Certain formulation, such as Rasa Parpam, (mentioned in Agasthiyar Paripuranam) and Chitramoolathy Mathirai (mentioned in Veeramamuni Nasa Kandam) have been evaluated in experimental studies and demonstrated apoptosis - inducing potential in HeLa and SiHa cell lines. This review underscores the importance of integrating traditional Siddha knowledge with modern scientific validation for potential cervical cancer management.