Erythroferrone derived from osteoblasts regulates stress erythropoiesis.

Key Points

• This research aims to uncover how erythroferrone derived from osteoblasts affects stress erythropoiesis and red blood cell recovery.
• Analyzed the effects of ERFE loss from osteoblasts on RBC recovery during stress erythropoiesis.
• Evaluated erythroid lineage proliferation and EPO responsiveness in a BMP4-dependent model.
• Utilized mutant models to assess regulatory interactions between osteoblasts and erythroblasts.
• ERFE loss from osteoblasts significantly enhances RBC recovery during stress erythropoiesis.
• Mutant models exhibited increased erythroid lineage proliferation and enhanced responsiveness to EPO.
• Crosstalk between osteoblasts and erythroblasts was crucial in defining stress erythropoiesis mechanisms.