A series of substituted pyrazolines were synthesized using a procedure that is simple, efficient, and environmentally friendly. The reaction between acrolein and α, β-enone in the presence of phenylhydrazine results in the formation of simple pyrazoline through cyclization. The straightforward work-up of the product under mild conditions, along with the rapid reaction, is a significant feature of the synthesis of pyrazolines. Additionally, the structures of the pyrazoline derivatives were elucidated through IR, 1H NMR, and mass spectral analysis. The compounds were assessed for their antibacterial activity against both Gram-positive and Gram-negative bacteria.
Shirsat et al. (Sat,) studied this question.