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This work examines how structural design and site-specific conjugation of bispecific ADCs can improve targeting of tumor tissues while minimizing effects on healthy tissues.

May 5, 2026

Structural design and site-specific conjugation in bispecific ADCs

Key Points

This work examines how structural design and site-specific conjugation of bispecific ADCs can improve targeting of tumor tissues while minimizing effects on healthy tissues.
Interview with experts in biologics core technologies
Discussion on design strategies for bispecific ADCs
Analysis of stability and safety considerations for complexes
Emphasis on the role of controlled conjugation and specificity in ADC efficacy
Insights on how precise payload placement can affect ADC stability
Highlights concerns regarding safety in targeting tumor heterogeneity

Abstract

“...we know that the specificity of our antibodies and their controlled conjugation helps us target tumor tissue while avoiding engagement with healthy tissues...”Lauren Coyle, Launch Commissioning Editor, Bioconjugate Insights, speaks with Sarka Stehlikova, Director, Biologics Core Technologies, SOTIO, about the design of bispecific ADCs for addressing tumor heterogeneity. They discuss the importance of site-specific conjugation and DAR control, and how precise payload placement influences stability and safety in complex ADC architectures.

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Authors

Šárka Stehlíková

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United Technologies Research Center

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Structural design and site-specific conjugation in bispecific ADCs

Key Points

Abstract

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Discussion

Authors

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References and Citations

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