Introduction: Cancer is a continued health burden across the world, and the existing cancer treatments, including chemotherapy, radiotherapy, and surgery, have been associated with several toxic side effects. The increasing interest in the use of herbal medicine and phytochemicals from medicinal plants is attributed to their potential as complementary treatments that can enhance cancer therapy, reduce toxicities, and improve existing treatments. Evidence for their use has continued to increase. Methods: The review was conducted by thoroughly evaluating the published literature on the therapeutic efficacy of herbal medicines and plant-derived phytochemicals in treating cancer. A number of clinical and preclinical studies were also assessed to understand the mechanisms and safety profiles associated with their therapeutic efficacy in combating cancer. Results: The results indicate the potential of different herbal medicines and phytochemicals with significant anticancer properties, which can act by inducing apoptosis, inhibiting tumor cell proliferation, interfering with various cellular processes, or boosting the immune system. Discussion: Recent developments in scientific knowledge and the applications of herbal drugs make their potential use in cancer treatment significant. Even though the initial outcomes are quite promising, the lack of appropriate frameworks and quality control during the implementation of herbal drugs is challenging. Conclusion: The review forms the basis for the safe, effective, and scientifically approved use of herbal medicines in the treatment of cancer. It makes an important contribution to the rational use of herbal medicines in the treatment of cancer by highlighting the drawbacks of existing conditions and opportunities to address them.
Panda et al. (Tue,) studied this question.