0468 Cannabis Use in Pregnant Women Seeking Treatment for Insomnia

Abstract Introduction Introduction. Prenatal sleep problems are common with half of women developing insomnia by the end of pregnancy. Cannabis use during pregnancy has recently increased due to the perceived benefits for pregnancy-related discomforts including insomnia. The present study sought to describe the rates of cannabis use among pregnant women seeking treatment for insomnia. Moreover, we characterized the sociodemographics and clinical presentations of pregnant women with current or former cannabis use. Methods Methods. Four-hundred-and-seven pregnant women (Age: 30. 7±4. 9yrs; Gestation: 25. 7±3. 4wks, 47. 8% non-white) seeking insomnia treatment in a large health system completed an online health survey. Outcomes included sociodemographics, Insomnia Severity Index (ISI), Edinburgh Postnatal Depression Scale (EPDS), suicidal ideation (EPDS item#10), Perinatal Rumination Scale-Night (PRS-Night), and cannabis use (never, former, current use). Results Results. Most patients denied any history of cannabis use (n=270/407; 66. 3%), whereas 127 patients endorsed former use (31. 2%). A smaller proportion reported current cannabis use during pregnancy (n=10/407; 2. 5%). Sociodemographic comparisons showed that current users were younger than former and never users (current vs former vs never: age 31. 28±4. 62 vs 29. 73±5. 14 vs 26. 40±4. 50, p. 001), reported lower income (50K rates: 80. 0% vs 48. 8% vs 25. 2%), and were least likely to be in a committed relationship (60. 0% vs 76. 3% vs 91. 1%, p. 001). Regarding clinical presentation, current users reported the highest severity of insomnia (ISI: 17. 40±4. 20 vs 15. 20±5. 36 vs 13. 03±5. 22, p. 001), depression (EPDS: 15. 50±6. 40 vs 11. 08±55. 57 vs 8. 83±5. 11, p. 001), and perinatal rumination (PRS-Night: 27. 40±10. 53 vs 20. 45±10. 00 vs 16. 48±9. 30, p. 001). Current users endorsed higher rates of suicidal ideation (30. 0%) than former users (19. 8%) and never users (8. 5%). Conclusion Conclusion. Pregnant women using cannabis are younger, lower income, and less likely to be in a committed relationship than those who formerly or never used. Current users have poorer sleep, greater depression, worse perinatal rumination, and more suicidal thoughts than pregnant women who quit or never used. Given the growing rates of cannabis use during pregnancy, these data highlight that cannabis use is highest among women from vulnerable segments of the population, and that cannabis use is linked to greater sleep and mood pathology, despite any ostensible benefits cannabis might be perceived to have. Support (if any) Support: R34MH130562, PI: Kalmbach.