Background: Deep medullary vein (DMV) drainage has been suggested as a new biomarker for predicting clinical outcomes in patients with acute ischemic stroke (AIS). We evaluated this hypothesis in patients who received endovascular treatment (EVT) within 24 h of symptom onset. Methods: We performed a retrospective study of consecutive AIS patients at a single institution treated with EVT achieving successful recanalization (final mTICI score ≥2b). DMV drainage was graded on a three-point scale (0-1-2) during the second peak venous phase of mCTA by assessing contrast filling, with grade 2 indicating a favorable DMV profile. Our primary outcomes were functional independence, defined as a modified Rankin Scale (mRS) score of 0–2 at 90 days, and ordinal mRS shift at 90 days. Secondary outcomes were excellent clinical status (mRS 0–1 at 90 days), hemorrhagic transformation, and symptomatic intracranial hemorrhage. We investigated independent associations using multivariable logistic and ordinal regression analyses as appropriate, adjusting for age, sex, baseline mRS, NIHSS at onset, occlusion site, intravenous thrombolysis, onset-to-CT time, and ASPECTS. Results: We included 506 patients; the mean age was 76 years. A favorable DMV profile was present in 394 (78%) patients. We found that DMV doubled the odds of achieving functional independence (OR = 2.22; 95% CI = 1.28–3.85) and was associated with a shift towards better functional outcomes in ordinal regression analysis (cOR = 1.93; 95% CI = 1.24–3.02), whereas we did not find any association between a favorable DMV profile and secondary outcomes. Conclusions: In AIS patients successfully recanalized with EVT, a favorable DMV profile was associated with better functional outcomes. Further investigations may clarify the clinical use and predictive ability of this novel radiological marker.
Busto et al. (Fri,) studied this question.