Bisoprolol fumarate combined with nifedipine significantly improved total clinical efficacy and blood pressure compared to nifedipine alone in patients with diastolic hypertension (P<0.05).
RCT (n=90)
Random number table
No
Does bisoprolol combined with nifedipine improve clinical efficacy and blood pressure control in patients with diastolic hypertension compared to nifedipine alone?
Combining bisoprolol with nifedipine provides superior blood pressure control, endothelial function improvement, and oxidative stress reduction in diastolic hypertension compared to nifedipine monotherapy.
p-value: p=<0.05
摘要： 目的 探讨联用富马酸比索洛尔片与硝苯地平控释片治疗舒张性高血压的效果与价值。 方法 前瞻性纳入2023年6月—2024年6月济南市第三人民医院收治的舒张性高血压患者90例为研究对象，根据随机数表法分为对照组和观察组，每组45例。对照组接受硝苯地平控释片治疗，观察组在对照组基础上联合富马酸比索洛尔片治疗。比较两组临床疗效、血压控制情况、血管内皮功能指标、心率变异性指标及氧化应激反应指标。 结果 观察组总有效率高于对照组，差异有统计学意义（PP>0.05）；治疗后，两组DBP、SBP水平均低于治疗前，且观察组低于对照组，差异有统计学意义（PP>0.05）；治疗后，两组NO水平均高于治疗前，且观察组高于对照组，差异有统计学意义（PP50 ms的计数占总RR间期数的百分比（PNN50）水平比较，差异无统计学意义（P>0.05）；治疗后，两组SDNN、RMSSD、PNN50水平均高于治疗前，且观察组高于对照组，差异有统计学意义（PP>0.05）；治疗后，两组SOD、GSH-Px水平均高于治疗前，且观察组高于对照组，差异有统计学意义（PP 结论 联用富马酸比索洛尔片与硝苯地平控释片治疗舒张性高血压不仅可以显著提高临床总有效率，还能够更明显改善血压水平、血管内皮功能指标、心率变异性指标及氧化应激反应指标。
Zaizhong GAO (Sun,) conducted a rct in Diastolic hypertension (n=90). Bisoprolol fumarate combined with nifedipine controlled-release tablets vs. Nifedipine controlled-release tablets was evaluated on Total clinical effective rate (p=<0.05). Bisoprolol fumarate combined with nifedipine significantly improved total clinical efficacy and blood pressure compared to nifedipine alone in patients with diastolic hypertension (P<0.05).