Extensive cerebral venous thrombosis associated with severe hyperhomocysteinemia in a child: a case report.

Pediatric cerebral venous thrombosis (CVT) is a rare and life-threatening condition, and hyperhomocysteinemia serves as a significant risk factor. We report an 11-year-old female presenting with blurred vision, gait instability, nausea, vomiting, and a persistent one-week headache. Her medical history of congenital ectopia lentis and prior bone fracture offered a pivotal diagnostic lead. Brain magnetic resonance imaging (MRI) confirmed extensive dural sinus thrombosis, and laboratory testing revealed severe hyperhomocysteinemia. The therapeutic regimen included anticoagulation, vitamin B6 supplementation, and thrombectomy of the venous sinus. After 15 days of treatment, the patient demonstrated significant amelioration of headache and motor deficits. Therefore, monitoring serum homocysteine levels is crucial in the management of CVT to ensure a comprehensive assessment of the patient's condition and therapeutic efficacy.