Key result
Anticoagulation, vitamin B6, and venous thrombectomy relieve pediatric CVT deficits within 15 days.
Case Report (n=1)
Highlights the importance of monitoring serum homocysteine levels and considering hyperhomocysteinemia in pediatric patients presenting with cerebral venous thrombosis.
Pediatric cerebral venous thrombosis (CVT) is a rare and life-threatening condition, and hyperhomocysteinemia serves as a significant risk factor. We report an 11-year-old female presenting with blurred vision, gait instability, nausea, vomiting, and a persistent one-week headache. Her medical history of congenital ectopia lentis and prior bone fracture offered a pivotal diagnostic lead. Brain magnetic resonance imaging (MRI) confirmed extensive dural sinus thrombosis, and laboratory testing revealed severe hyperhomocysteinemia. The therapeutic regimen included anticoagulation, vitamin B6 supplementation, and thrombectomy of the venous sinus. After 15 days of treatment, the patient demonstrated significant amelioration of headache and motor deficits. Therefore, monitoring serum homocysteine levels is crucial in the management of CVT to ensure a comprehensive assessment of the patient's condition and therapeutic efficacy.
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Han et al. (2026) conducted a case report in Cerebral venous thrombosis and severe hyperhomocysteinemia (n=1). Anticoagulation, vitamin B6 supplementation, and thrombectomy was evaluated on Amelioration of headache and motor deficits. Treatment with anticoagulation, vitamin B6 supplementation, and venous sinus thrombectomy led to significant amelioration of headache and motor deficits after 15 days in an 11-year-old female with CVT.
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