What question did this study set out to answer?

This study aims to identify and evaluate the antidiabetic potential of sesquiterpenoids from Alpinia oxyphylla fruits.

May 27, 2026

Diverse Sesquiterpenoids With Antidiabetic Potency From the Fruits of Alpinia oxyphylla

Key Points

This study aims to identify and evaluate the antidiabetic potential of sesquiterpenoids from Alpinia oxyphylla fruits.
Five new and 13 known sesquiterpenoids were isolated from A. oxyphylla fruits.
Structural determination was performed using NMR and spectroscopic data.
Cellular glucose uptake and enzyme inhibition assays were conducted to assess antidiabetic activity.
Compounds 1, 2, and 5 increased glucose uptake by 15.0%, 10.3%, and 20.7% at 20 µM respectively.
Compound 3 inhibited αglucosidase and PTP1B activity with rates of 42.5% and 21.5% at 200 µM.
Eremophilane-type sesquiterpenoids demonstrate potential as antidiabetic agents.

Abstract

ABSTRACT Five new sesquiterpenoids, alpinoxyphyllols C‒G ( 6 ‒ 10 ), and 13 known ones were isolated from the fruits of Alpinia oxyphylla . Their structures were determined by extensive 1D and 2D NMR, HRESIMS, α D , and ECD spectroscopic data, and quantum chemical calculation. Compounds 1 , 2, and 5 could promote the cellular glucose uptake by 15.0 %, 10.3 % and 20.7 % at 20 µM. Compound 3 showed inhibitory activity against both αglucosidase and PTP1B with inhibition rates of 42.5 ± 1.2% and 21.5 ± 1.6% at 200 µM. This study manifests that the eremophilane‐type sesquiterpenoids in A. oxyphylla possess promising anti‐diabetic potential and warrant further investigation.

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