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May 31, 2026Open Access

Electrocardiographic Changes in Chronic Schizophrenic Patients

Key Points

The study aims to assess electrocardiographic changes in chronic schizophrenic patients receiving trifluoperazine.
Compared ECGs of 43 experimental and 60 control patients
Administered 4 mg of trifluoperazine daily by IM route for five days
Conducted three 12-lead ECGs for each patient
Significant ECG changes observed in the experimental group, particularly in older patients
More pronounced changes were noted in patients over 45 years
Statistical analysis confirmed significant variations in ECG variables

Abstract

The electrocardiograms were compared in two groups of schizophrenic patients (Experimental group N=43, Control group N=60). The selected cases were given 4 mg of Trifluoperazine daily by IM route for five days. A 12 lead ECG was taken thrice in each case. A statistical analysis of the data showed definite changes in many of the ECG variables. Comparatively more changes were noticed in the experimental group and in patients beyond the age of 45 years.

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