Tubulointerstitial Nephritis and Uveitis Syndrome in an Adolescent Female: A Case Report

Key Points

• To present a case of Tubulointerstitial Nephritis and Uveitis (TINU) syndrome in an adolescent and discuss treatment outcomes.
• A 14-year-old female presented with fever, weight loss, and bilateral eye pain leading to hospitalization.
• Kidney biopsy confirmed diffuse tubulointerstitial nephritis without glomerular lesions.
• Treatment included steroid eye drops, pulse therapy, and short-term adalimumab following recurrent uveitis.
• Initial treatment led to improvement in symptoms and clinical remission.
• Recurrent uveitis occurred twice during tapering of prednisolone despite mycophenolate mofetil.
• Short-term adalimumab therapy successfully prevented further recurrences, allowing for tapering and discontinuation of prednisolone.