Study on the neuroprotective mechanism of electroacupuncture in regulating the p38/SIRT1/FoxO1 signaling pathway in Parkinsons disease

Key Points

• The research investigates the effects of electroacupuncture on motor function and oxidative stress in a Parkinson's disease mouse model.
• 36 C57BL/6 mice randomly assigned to control, model, and electroacupuncture groups, with N=12 each.
• MPTP administered for 7 days to replicate Parkinson's disease model; electroacupuncture performed at specific acupoints for 14 days.
• Behavioral assessments and various biochemical analyses (Western blot, qPCR) conducted to evaluate changes.
• MPTP group showed significantly reduced motor distance and hanging scores (P<0.01) with decreased TH-positive neurons.
• MPTP+EA group exhibited improvements in motor function and increased TH and SIRT1 protein levels, with significant changes in mRNA expression levels (all P<0.01).