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June 3, 2026Lishizhen medicine and materia medica research

Study on the neuroprotective mechanism of electroacupuncture in regulating the p38/SIRT1/FoxO1 signaling pathway in Parkinsons disease

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Authors

PYPeihao YUYWYifei WangWZWei Zhou

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Overview

Randomized trial explores the impact of electroacupuncture on motor function in Parkinson's disease mice, suggesting a mechanism involving specific signaling pathways.

Key Points

  • The research investigates the effects of electroacupuncture on motor function and oxidative stress in a Parkinson's disease mouse model.
  • 36 C57BL/6 mice randomly assigned to control, model, and electroacupuncture groups, with N=12 each.
  • MPTP administered for 7 days to replicate Parkinson's disease model; electroacupuncture performed at specific acupoints for 14 days.
  • Behavioral assessments and various biochemical analyses (Western blot, qPCR) conducted to evaluate changes.
  • MPTP group showed significantly reduced motor distance and hanging scores (P<0.01) with decreased TH-positive neurons.
  • MPTP+EA group exhibited improvements in motor function and increased TH and SIRT1 protein levels, with significant changes in mRNA expression levels (all P<0.01).

Cite This Study

YU et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc5b7dee9eb8c0dce7163https://doi.org/10.70976/j.1008-0805.szgygy-2026-1022
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Research of EA on mitophagy in the midbrain substantia nigra of 1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine mice2026
  2. 2[Inhibitory effect of electroacupuncture on microglial activation via Notch1/Hes1 pathway in Parkinson's disease mice].2025
  3. 3[Effects of electroacupuncture on cognitive impairment and mitophagy mediated by KIF5A/Miro1 pathway in Parkinson's disease mice].2025 · 1 citations
  4. 4Electroacupuncture at ST25 corrected gut microbial dysbiosis and SNpc lipid peroxidation in Parkinson’s disease rats2024 · 15 citations
  5. 5Effects of electroacupuncture on mitophagy mediated by SIRT3/PINK1/Parkin pathway in Parkinson's disease mice.2024 · 2 citations