Inhibition of Amyloid-β and α-Synuclein Oligomer-induced NLRP3 Inflammasome Activation by NDGA in Microglia: A Promising Anti-inflammatory Strategy for Neurodegeneration (S1.010) | Synapse
Inhibition of Amyloid-β and α-Synuclein Oligomer-induced NLRP3 Inflammasome Activation by NDGA in Microglia: A Promising Anti-inflammatory Strategy for Neurodegeneration (S1.010)
The central aim is to assess the effect of NDGA on NLRP3 inflammasome activation triggered by amyloid-β and α-synuclein in microglial cells.
Exposure of microglial cells to amyloid-β and α-synuclein oligomers
Treatment with NDGA to evaluate its inhibitory effect on inflammasome activation
NDGA significantly reduced NLRP3 inflammasome activation in treated microglial cells.
Inhibition of pro-inflammatory mediators was observed following NDGA treatment.
Abstract
This study aimed to determine whether nordihydroguaiaretic acid (NDGA) can reduce NLRP3 inflammasome activation in microglial cells exposed to amyloid-β (Aβ) and α-synuclein (α-syn) oligomers.