We present the QRCL Multi-Messenger Framework (QRCL-MMF), a systematic open-source pipeline for rigorous vetting of exoplanet biosignature candidates. The framework integrates JWST transmission spectroscopy (NIRSpec + MIRI LRS), TESS TTV O–C residuals, Gaia DR3 stellar astrometry, and photometric data into a unified Bayesian log-evidence framework requiring Z>10 across dual spectral bands plus abiotic rejection for any claim. Results: TRAPPIST-1 d/e TTV residuals (4 TESS SPOC transits, PRELIMINARY); K2-18 b DMS Z≈3.5 (TENTATIVE; MIRI confirmation required); zero JWST public spectra found for 5 priority targets in MAST. No biosignature claimed. All data public; all evidence SHA-256 hashed.
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