A physical derivation of cardiac electromechanics from first principles uniformly explained nine core observational facts of cardiac physiology.
Provides a novel theoretical framework deriving cardiac electromechanics from physical first principles to unify disparate physiological observations.
Cardiac physiology has accumulated nine core observational facts: the necessity of pulsation, sinoatrial node autonomous pacing, the all-or-none action potential, the topological differentiation of arteries and veins, the near-absence of cardiomyocyte division, heart failure with preserved ejection fraction, tachycardia-induced heart failure, the age-dependent decline in maximum heart rate, and the irreversible progression of atrial fibrillation. These facts are currently dispersed across separate chapters of electrophysiology, hemodynamics, and pathophysiology. This paper proposes that they can be uniformly explained within a single physical framework: the heart is the dissipation center geometrically predetermined at the very moment of energy injection in a multicellular aggregate. This paper provides a complete physical derivation of cardiac electromechanics from first principles, and tests each core deduction against three categories of independent public data—cross-species embryogenesis timelines, clinical data of birth circulatory transition, and cross-species allometric scaling data. All test results support the derivation. All tests use publicly available data and standard statistical methods and can be independently reproduced by any researcher. This paper presupposes no specific biological theory; it proceeds from known physical laws and tests each deductive step against independent data.
Menggang Yu (Sun,) reported a other. A physical derivation of cardiac electromechanics from first principles uniformly explained nine core observational facts of cardiac physiology.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: