Palladium Direct Arylation and Annulation for the Catalyzed Regiocontrolled Synthesis of Quinolone Derivatives

Key Points

• The aim is to develop a palladium-catalyzed method for synthesizing quinolone derivatives from specific substrates.
• Utilized a one pot synthesis strategy using (hetero)arylamides and functionalized 1,2-dihalobenzenes.
• Proposed a reaction mechanism likely involving Pd 1,4-migration.
• Successfully synthesized various quinolone derivatives.
• Showed effective regiocontrolled transformations.