The concept of information as a physical primitive — causally efficacious, independent of energy transfer, and operative across scales from quantum to psychophysiological — has been implicit in a century of anomalous experimental results and explicit in a growing number of theoretical frameworks, none of which has yet provided a mathematically complete and empirically falsifiable account. This paper proposes such an account. We introduce the information field ΨI as a fundamental physical primitive defined on configuration space rather than spacetime, whose degrees of freedom are relational invariants — phase relationships, symmetry structures, and topological links — rather than field values at spacetime points. The theoretical foundation draws on Bohm and Hiley's process algebra 19, 20 and active information formalism, extended with the mathematical language of topological quantum field theory, and grounded in an explicit ontological framework in which organizational structure is irreducible to energy and matter. The framework is motivated by empirical results from Faraday-shielded autonomic nervous system synchrony experiments conducted at UNICAMP, in which statistically significant physiological correlations between electromagnetically isolated human subjects were observed at 250 meters separation (p < 0. 01) 18, 1, 12, and is developed to account for the full class of phenomena — from quantum nonlocality through biological coherence to psychophysiological coupling — that share the structural signature of organizational correlation without energetic transfer. A five-stage transduction cascade is formally derived, connecting ΨI's implicate organizational structure to measurable physiological responses across scales. Seven falsifiable predictions are generated from the mathematical structure of the framework. A critical experiment is designed — intercontinental distance, double-blind, three-condition within-session, millisecond-precision GPS timestamp synchronization, 32-channel EEG, independent blinded analysis, pre-registered — that closes all major loopholes simultaneously and reaches the burden inversion threshold: if its results confirm the primary prediction, the only remaining objection requires a more implausible set of assumptions than the ΨI account itself. The paper includes an explicit self-criticism of an earlier formulation of the theory, a structured comparison with six competing frameworks against three evaluation criteria, and a commitment to open data and independent replication as conditions for claiming the results as established. What is proposed here is not a final theory. It is a mathematically precise, empirically falsifiable, and ontologically honest first step toward a physics that takes organizational structure as seriously as it takes energy and matter.
Azevedo et al. (Tue,) studied this question.
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