Elevated NRIR expression was independently associated with a significantly increased risk of major adverse cardiovascular events (OR 6.89) in patients with acute myocardial infarction.
Observational (n=226)
No
Does elevated NRIR expression predict major adverse cardiovascular events and diagnose acute myocardial infarction in patients undergoing coronary angiography?
Elevated NRIR expression is a potential diagnostic and prognostic biomarker for acute myocardial infarction, independently predicting a higher risk of MACE at 6 months.
Odds Ratio: 6.89 (95% CI 2.86–18.12)
p-value: p=<0.001
Negative regulator of interferon response (NRIR) expression was upregulated in patients with acute myocardial infarction (AMI) and in oxygen-glucose deprivation-induced cardiomyocytes.Elevated NRIR levels were associated with progression of AMI and poor prognosis, indicating its potential as a diagnostic and prognostic biomarker for AMI.Mechanistically, NRIR aggravates cardiomyocyte injury by modulating the miR-515-5p/SLC40A1 axis, leading to enhanced oxidative stress, mitochondrial dysfunction, and apoptosis.These findings suggest that targeting the NRIR/miR-515-5p/SLC40A1 axis may offer a novel therapeutic strategy for alleviating myocardial injury and improving clinical outcomes in AMI.
Wang et al. (Wed,) conducted a observational in Acute Myocardial Infarction (n=226). Elevated NRIR expression vs. Low NRIR expression was evaluated on Major adverse cardiovascular events (MACE) (OR 6.89, 95% CI 2.86-18.12, p=<0.001). Elevated NRIR expression was independently associated with a significantly increased risk of major adverse cardiovascular events (OR 6.89) in patients with acute myocardial infarction.