Key result
Elevated NRIR expression was independently associated with a significantly increased risk of major adverse cardiovascular events (OR 6.89) in patients with acute myocardial infarction.
Why the study?
Does elevated NRIR expression predict major adverse cardiovascular events and diagnose acute myocardial infarction in patients undergoing coronary angiography?
Observational (n=226)
No
Does elevated NRIR expression predict major adverse cardiovascular events and diagnose acute myocardial infarction in patients undergoing coronary angiography?
Elevated NRIR expression is a potential diagnostic and prognostic biomarker for acute myocardial infarction, independently predicting a higher risk of MACE at 6 months.
Negative regulator of interferon response (NRIR) expression was upregulated in patients with acute myocardial infarction (AMI) and in oxygen-glucose deprivation-induced cardiomyocytes.Elevated NRIR levels were associated with progression of AMI and poor prognosis, indicating its potential as a diagnostic and prognostic biomarker for AMI.Mechanistically, NRIR aggravates cardiomyocyte injury by modulating the miR-515-5p/SLC40A1 axis, leading to enhanced oxidative stress, mitochondrial dysfunction, and apoptosis.These findings suggest that targeting the NRIR/miR-515-5p/SLC40A1 axis may offer a novel therapeutic strategy for alleviating myocardial injury and improving clinical outcomes in AMI.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2026) conducted an observational in Acute Myocardial Infarction (n=226). Elevated NRIR expression vs. Low NRIR expression was evaluated on Major adverse cardiovascular events (MACE) (OR 6.89, 95% CI 2.86-18.12, p=<0.001). Elevated NRIR expression was independently associated with a significantly increased risk of major adverse cardiovascular events (OR 6.89) in patients with acute myocardial infarction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: