Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods

Key Points

• To investigate the maturation process of the human endocrine pancreas during early postnatal periods.
• Analyzed 123 pediatric pancreata through systematic histological examination.
• Assessed islet formation, cell rearrangement, vascularization, and glucagon secretion dynamics.
• Detailed dynamic islet formation observed in the first decade of life.
• Noted asynchronous patterns in vascularization and innervation.
• Progressive glucagon secretion maturation was documented over early childhood.