Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing–Remitting Multiple Sclerosis

Key Points

• This research aims to explore the association between paramagnetic rim lesions and choroid plexus volume with cognitive progression in early relapsing-remitting multiple sclerosis.
• Evaluated 87 early relapsing-remitting MS patients at diagnosis and followed them longitudinally.
• Measured paramagnetic rim lesions and choroid plexus volume via 3 T-MRI at diagnosis.
• Classified cognitive decline as cognitive progression independent of relapse/MRI activity.
• 55 patients (63.2%) experienced significant cognitive decline; 44 (80.0%) met criteria for cognitive progression independent of relapse/MRI activity.
• Paramagnetic rim lesions and larger choroid plexus volume were significantly associated with cognitive progression.
• Findings support the role of PRLs and CP volume as markers of smoldering disease activity.