Abstract The combination of multidrug resistance and general toxicity and nonspecific tissue damage restricts traditional chemotherapy from achieving its full potential in cancer treatment. Phytochemicals extracted from plants have emerged as a promising chemotherapy adjuvant during the last decade. Phytochemicals function as therapeutic agents, which enhance the effectiveness of anticancer medications when used together. The review examines all molecular pathways that enable phytochemicals to enhance chemotherapy drug performance through drug efflux inhibition and apoptosis and cell cycle modification and prosurvival signaling suppression and epigenetic regulation. The essential phytochemicals curcumin, resveratrol, quercetin, genistein, and epigallocatechin gallate demonstrate their ability to enhance drug effectiveness and combat drug resistance while reducing side effects in both laboratory studies and human clinical trials. The therapeutic potential of these combinations has improved through nanotechnology-based codelivery systems, which enhance their delivery and effectiveness. The promising results face challenges because of pharmacokinetic differences and insufficient clinical data and inconsistent treatment protocols. Researchers will use systems biology together with nanotechnology and personalized medicine to develop safe and effective therapeutic approaches from these synergistic combinations. The strategic addition of phytochemicals to standard cancer treatments shows promise for developing new oncological therapies, which deliver better results with reduced adverse effects.
Sharfudeen et al. (Mon,) studied this question.
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