Association of spontaneous and procedure-related bleeds with short- and long-term mortality after acute coronary syndromes: an analysis from the PLATO trial

Structured PICO

Does spontaneous bleeding compared to procedure-related bleeding increase short- and long-term mortality in patients with acute coronary syndromes?

Population

Patients with acute coronary syndromes (ACS) from the PLATO trial

Intervention

Spontaneous bleeding (as an exposure)

Comparator

Procedure-related bleeding

Outcome

Short- and long-term mortalityhard clinical

In patients with acute coronary syndromes, spontaneous bleeding carries a significantly stronger association with early mortality than procedure-related bleeding.

Abstract

Major bleeding is associated with high subsequent mortality in ACS. However, this association is much stronger in the first 30 days and is strongest for spontaneous (vs. procedure-related) bleeding.

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