Figure S13 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• Cytokine secretion from HER2.CAR T cells increased following repeated stimulation with EPN cells, showing promise.
• Increased levels of cytokines indicate that CAR T cells can be effective in targeting ependymomas despite limitations.
• Assessment revealed that tumor size and immune response may significantly influence the effectiveness of CAR T cell therapy.
• Findings suggest further investigation into overcoming identified challenges in CAR T cell treatment for ependymomas.