High-Resolution Multi-Contrast Distortion-free DWI for Motion-Sensitive Patients：Integrating EPTI with Prospective Motion Correction

Motivation: Diffusion-weighted imaging (DWI) is integral to clinical diagnostics but is sensitive to geometric distortions caused by B0 inhomogeneity. Due to its low SNR and longer scan times, it is also sensitive to blurring and signal loss related to. Goal(s): Achieve high-resolution, distortion-free, and motion-robust DWI for motion-sensitive patients. Approach: We combine echo planar time-resolved imaging (EPTI) with markerless prospective motion correction (PMC) and utilize a locally low-rank subspace reconstruction to obtain high-resolution, multi-contrast, distortion-free DWI. Results: The PMC system facilitates real-time correction of head motion, ensuring that the 1×1×5mm3 target resolution is achieved, as well as multi-contrast, distortion-free DWI. Impact: The integration of EPTI with PMC enhances DWI's clinical utility by providing high-resolution(1×1×5 mm3), distortion-free imaging for motion-sensitive patients, including children and patients with Alzheimer's disease.