Muscle Glucose Uptake using Deuterium Metablic Imaging (DMI) at 7T

Motivation: We wished to determine the feasibility of using deuterium metabolic imaging (DMI) for assessing glucose metabolism in human leg muscles in normal volunteers to establish a baseline for future work in muscular diseases. Goal(s): The goal of this study is to determine whether DMI could be used in muscles for establishing baseline measurements. Approach: We used 6,6-2H-glucose and 2H-MRSI at 7T to assess glucose metabolism in eight normal participants between 10 minutes and two hours. Results: Small changes were observed in muscle ²H-glucose signal intensity between the initial and final scans. Muscle ²H-glucose or ²H-Glx levels varied among participants, suggesting differential metabolism. Impact: Deuterated metabolic imaging (DMI) has the potential to revolutionize the assessment of muscle glucose metabolism, enabling clinicians to better diagnose and manage musculoskeletal disorders. This research establishes baseline methods before applying DMI in musculoskeletal disorders.