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September 17, 2025

Quantifying Hepatic Arterial Blood Flow with 4D Flow MRI to Improve Transarterial Radioembolization: a Feasibility and Repeatability Study

Key Points

Quantifying hepatic arterial blood flow using 4D flow MRI is feasible yet shows variability in reliability.
In a study of 20 volunteers and 10 patients, large variations were observed in scan-rescan reliability metrics.
The technique may enable investigations of the relationship between hepatic arterial blood flow and microsphere distribution in TARE.
Understanding scan-rescan differences is crucial for validating 4D flow MRI as a tool for improving TARE outcomes.

Abstract

Motivation: Hepatic arterial blood flow (HABF) is expected to be an important parameter influencing the microsphere distribution during transarterial radioembolization (TARE). Goal(s): This study aimed to assess the ability of 4D flow MRI (3D time-resolved phase-contrast MRI with 3D velocity encoding) to quantify HABF. Approach: An in vivo feasibility and repeatability (scan-rescan reliability) study was conducted in twenty volunteers, followed by a feasibility study in ten patients with a liver disease. Results: Quantifying HABF with 4D flow MRI is feasible, but there are large variations in scan-rescan reliability. Further analyses are planned to understand the (variation in) scan-rescan differences. Impact: If hepatic arterial blood flow (HABF) quantification with 4D flow MRI proves feasible and repeatable, the technique can be used to investigate the relationship between HABF and transarterial radioembolization (TARE) microsphere distribution, with the ultimate goal of improving TARE outcomes.

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Cite This Study

Brekel et al. (Tue,) studied this question.

synapsesocial.com/papers/68d45b1b31b076d99fa5d5c3 https://doi.org/https://doi.org/10.58530/2025/3517

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