Chiral pool-engineered homochiral covalent organic frameworks for catalytic asymmetric synthesis of drug intermediate

Key Points

• The study reports a 95% yield and 93% ee in asymmetric Henry reactions using engineered COFs.
• Chiral-pool strategy involved constructing cysteine-derived thiazoline frameworks with efficient catalysis.
• Nanofiber-like structures exhibited a two-dimensional eclipsed stacking arrangement, enhancing reaction efficiency.
• This innovative approach to covalent organic frameworks may enable improved drug synthesis methodologies.