Chiral pool-engineered homochiral covalent organic frameworks for catalytic asymmetric synthesis of drug intermediate

Q: What type of study is this?

This is a Experimental Study study.

Fei Li; Bing‐Jian Yao; Jian Wang; Y. Leng; Wenbo Xu; Yu‐Bin Dong

doi:10.1039/d5cc04282h

January 1, 2025Chemical Communications

Chiral pool-engineered homochiral covalent organic frameworks for catalytic asymmetric synthesis of drug intermediate

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Key Points

The study reports a 95% yield and 93% ee in asymmetric Henry reactions using engineered COFs.
Chiral-pool strategy involved constructing cysteine-derived thiazoline frameworks with efficient catalysis.
Nanofiber-like structures exhibited a two-dimensional eclipsed stacking arrangement, enhancing reaction efficiency.
This innovative approach to covalent organic frameworks may enable improved drug synthesis methodologies.

Implication

Covalent organic frameworks demonstrate 95% yield and 93% ee in asymmetric synthesis, suggesting new possibilities for drug development.

Abstract

A chiral-pool strategy was employed to construct nanofiber-like cysteine-derived thiazoline COFs featuring a two-dimensional eclipsed (AA) stacking arrangement. The Cu(II)@(R)-THZTp achieved 95% yield and 93% ee in asymmetric Henry reactions....

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68e02f34f0e39f13e7fa22c5 https://doi.org/10.1039/d5cc04282h

View Full Paper

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Chiral pool-engineered homochiral covalent organic frameworks for catalytic asymmetric synthesis of drug intermediate

Key Points

Implication

Abstract

Discussion

Cite This Study

Chiral pool-engineered homochiral covalent organic frameworks for catalytic asymmetric synthesis of drug intermediate

Key Points

Implication

Abstract

Discussion

Cite This Study

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