Mp68-02 Association of Area of Deprivation Index With Prostate Cancer Incidence and Lethality Over a Contemporary North American Cohort

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History II (MP68)1 May 2024MP68-02 ASSOCIATION OF AREA OF DEPRIVATION INDEX WITH PROSTATE CANCER INCIDENCE AND LETHALITY OVER A CONTEMPORARY NORTH AMERICAN COHORT Marco Finati, Giuseppe O. Cirulli, Giuseppe Chiarelli, Alex Stephens, Shane Tinsley, Sohrab Arora, Patrick Etta, Mohit Butaney, Matthew J. Davis, Chase Morrison, Akshay Sood, Giovanni Lughezzani, Nicolò Buffi, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Carlo Bettocchi, Giuseppe Carrieri, Craig Rogers, and Firas Abdollah Marco FinatiMarco Finati , Giuseppe O. CirulliGiuseppe O. Cirulli , Giuseppe ChiarelliGiuseppe Chiarelli , Alex StephensAlex Stephens , Shane TinsleyShane Tinsley , Sohrab AroraSohrab Arora , Patrick EttaPatrick Etta , Mohit ButaneyMohit Butaney , Matthew J. DavisMatthew J. Davis , Chase MorrisonChase Morrison , Akshay SoodAkshay Sood , Giovanni LughezzaniGiovanni Lughezzani , Nicolò BuffiNicolò Buffi , Andrea SaloniaAndrea Salonia , Alberto BrigantiAlberto Briganti , Francesco MontorsiFrancesco Montorsi , Carlo BettocchiCarlo Bettocchi , Giuseppe CarrieriGiuseppe Carrieri , Craig RogersCraig Rogers , and Firas AbdollahFiras Abdollah View All Author Informationhttps://doi.org/10.1097/01.JU.0001008744.60568.e8.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The Area of Deprivation Index (ADI) could offer a distinctive and valuable metric for measuring the impact of socioeconomic status and residence in underprivileged areas on disparities in cancer outcomes. Our study examined the impact of ADI on Prostate Cancer (PCa) incidence and lethality over a contemporary North American population. METHODS: Our institutional database included electronic medical records for all men who received at least one PSA test within Henry Ford Health (HFH), between 1995-2019. An ADI score was assigned to each patient based on their residential census block group, ranked as a percentile of deprivation relative to the national level. All patients were further categorized into ADI quartile, where the highest quartile (Q4: 75-100) represented individuals with the most disadvantageous socio-economic status. The main outcomes were PCa incidence and lethal PCa, defined as any metastatic PCa or death due to PCa occurred within our cohort. Cumulative incidence curves depicted PCa incidence and lethality rates based on ADI quartile. Multivariable Fine-Gray regression tested the impact of ADI on PCa incidence and lethality, after adjusting for all available confounders. RESULTS: A total of 148,892 patients were included, with a median follow-up of 8.8 (5-17) years. When patients were categorized based on their ADI quartile, the 20-years PCa incidence rates were 9.1%, 8.4%, 7.7% and 8.5%% for the first, second, third and fourth quartile respectively. For the same quartile categories, the 20-years lethal PCa rates were 1.3%, 0.90%, 1.0% and 1.7%. At multivariable analysis, both the third (HR: 0.01, 95% IC: 0'85-0.97, p=0.007) and the fourth quartile (HR: 0.83, 95% IC: 0.77-0.88, p=0.007) had a lower risk of being diagnosed with PCa, when compared with patients in the first quartile. On the other side, ADI did not result an independent predictor for lethal PCa. Of note, Non-Hispanic Black patients had almost a double risk both for PCa incidence and lethality, when compared with the White counterparts (all p<0.001). CONCLUSIONS: Our study is the first to evaluate the role of ADI in predicting PCa incidence and lethality in a contemporary North American cohort. Patients from less disadvantaged areas were more likely diagnosed with PCa, while those from the most deprived areas showed increased lethal PCa rates, though not reaching the conventional significance at multivariable analysis. Notably, race emerged as an independent predictor for both lethal PCa and its incidence, regardless of any socioeconomic and deprivation influences. Source of Funding: Vattikuti Foundation and Menon Foundation © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1108 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Marco Finati More articles by this author Giuseppe O. Cirulli More articles by this author Giuseppe Chiarelli More articles by this author Alex Stephens More articles by this author Shane Tinsley More articles by this author Sohrab Arora More articles by this author Patrick Etta More articles by this author Mohit Butaney More articles by this author Matthew J. Davis More articles by this author Chase Morrison More articles by this author Akshay Sood More articles by this author Giovanni Lughezzani More articles by this author Nicolò Buffi More articles by this author Andrea Salonia More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Carlo Bettocchi More articles by this author Giuseppe Carrieri More articles by this author Craig Rogers More articles by this author Firas Abdollah More articles by this author Expand All Advertisement PDF downloadLoading ...