Mp32-07 Health-Related Quality of Life in Patients With Urethral Stenosis After Radiation Treatment for Prostate Cancer

You have accessJournal of UrologyReconstruction: Urethral Reconstruction (Including Stricture) II (MP32)1 May 2024MP32-07 HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH URETHRAL STENOSIS AFTER RADIATION TREATMENT FOR PROSTATE CANCER Kennedy Dirk and Keith F. Rourke Kennedy DirkKennedy Dirk and Keith F. RourkeKeith F. Rourke View All Author Informationhttps://doi.org/10.1097/01.JU.0001008816.80828.35.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: While many patients experience an uneventful recovery after radiation treatment for prostate cancer, urethral stenosis because of treatment is likely under-reported with a particular deficiency in patient-reported quality of life (QOL). This study aims to evaluate patient-reported QOL in patients presenting with urethral stenosis after prostate radiotherapy. METHODS: Patients presenting with urethral stenosis after radiotherapy were retrospectively reviewed from 2004-2022. PRQoL was assessed via patient survey using the Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP). Patients were surveyed either in person or by telephone using the Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) to assess health-related quality of life (HRQOL). RESULTS: 230 patients were identified with a mean age of 67.7 years and mean time to stenosis diagnosis of 63.6 months' post-radiotherapy. When surveyed, 29.9% of patients recalled being aware of urethral stenoses as a potential complication of radiation treatment and 51.7% had documentation during initial consultation specifically mentioning urethral stenosis as a potential complication. 33.5% of patients ultimately underwent urethroplasty, 59.6% opted for repeat endoscopic treatments and 6.1% were treated with an indwelling catheter. 64.4% of patients reported overall urinary function as either a "moderate" or "big" problem, 66.7% reported frequent or total incontinence, 64.4% required daily pad use and 50.6% felt urinary incontinence was either a "moderate" or "big" problem. Additionally, 47.1% of patients reported rectal pain and 31.0% reported dysuria. 85.0% reported poor or absent orgasmic dysfunction and 88.5% reported erections insufficient for any sexual activity. Depressive symptoms were reported by 41.4% of patients and 60.9% reported a lack of energy. CONCLUSIONS: Urethral stenosis after radiotherapy is a clinically complex entity with a broad scope of associated symptoms including high rates of patient-reported incontinence, voiding dysfunction, sexual dysfunction, pain, bowel dysfunction and depression. This multi-focal nature combined with often insidious presentation and patient unawareness creates a uniquely challenging condition to treat. Source of Funding: The Edna Wakefield Rowe Memorial Summer Research Award © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e517 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Kennedy Dirk More articles by this author Keith F. Rourke More articles by this author Expand All Advertisement PDF downloadLoading ...