Associations between methylglyoxal and cerebral small vessel disease and cognitive function – The Maastricht Study | Synapse
February 2, 2026Open Access
Associations between methylglyoxal and cerebral small vessel disease and cognitive function – The Maastricht Study
Key Points
This research aims to explore the relationship between methylglyoxal levels, cerebral small vessel disease, and cognitive function.
Analyzed plasma methylglyoxal levels in adults
Examined the presence of lacunar infarcts using imaging techniques
Performed statistical associations to determine correlations
Intermediate plasma methylglyoxal levels corresponded to a higher presence of lacunar infarcts
Further causal research is warranted to understand the role of methylglyoxal in infarct formation
Abstract
Intermediate plasma MGO levels were associated with the presence of more lacunar infarcts. Further research is needed to determine whether MGO contributes to lacunar infarct formation in a causal manner.