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January 1, 2026Journal of Stroke and Cerebrovascular DiseasesOpen Access

Associations between methylglyoxal and cerebral small vessel disease and cognitive function – The Maastricht Study

Eline Berends Simone J.P.M. Eussen Walter H. Backes P.C. Dagnelie Jacobus F.A. Jansen Bastiaan E. de Galan René Pool Sebastian Köhler Miranda T. Schram Anke Wesselius Robert J. van Oostenbrugge Sébastien Foulquier Casper G. Schalkwijk

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Key Points

This research aims to explore the relationship between methylglyoxal levels, cerebral small vessel disease, and cognitive function.
Analyzed plasma methylglyoxal levels in adults
Examined the presence of lacunar infarcts using imaging techniques
Performed statistical associations to determine correlations
Intermediate plasma methylglyoxal levels corresponded to a higher presence of lacunar infarcts
Further causal research is warranted to understand the role of methylglyoxal in infarct formation

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Implication

Research shows a link between methylglyoxal levels and lacunar infarcts in adults, suggesting potential health risks.

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Cite This Study

Berends et al. (2026) studied this question.

synapsesocial.com/papers/6980fcfcc1c9540dea80eb0e https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108578

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