Total Synthesis of (ent)-Linderolide E and (ent)-15-Hydroxy-and 15-Acetoxyisogermafurenolides, and Structural Revision of (ent)-Linderolide E

Key Points

• This research aims to achieve the total synthesis of specific sesquiterpenoids and revise their structures.
• Conducted total synthesis of (ent)-linderolide E and (ent)-15-hydroxy- and 15-acetoxyisogermafurenolides.
• Performed structural analysis to confirm revisions of (ent)-linderolide E.
• Successfully synthesized the targeted sesquiterpenoid compounds.
• Provided structural revisions that clarify the configuration of (ent)-linderolide E.