PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 2, 2026Organic & Biomolecular Chemistry2 citations

Total Synthesis of (ent)-Linderolide E and (ent)-15-Hydroxy-and 15-Acetoxyisogermafurenolides, and Structural Revision of (ent)-Linderolide E

View Full Paper
ASAnisha SureshMSMahendra R. ShingoleKKKrishna P. Kaliappan

Key Points

  • This research aims to achieve the total synthesis of specific sesquiterpenoids and revise their structures.
  • Conducted total synthesis of (ent)-linderolide E and (ent)-15-hydroxy- and 15-acetoxyisogermafurenolides.
  • Performed structural analysis to confirm revisions of (ent)-linderolide E.
  • Successfully synthesized the targeted sesquiterpenoid compounds.
  • Provided structural revisions that clarify the configuration of (ent)-linderolide E.

Abstract

Sesquiterpenoid scaffolds such as the eudesmane-type linderolides and elemanolide-type isogermafurenolides remain synthetically challenging despite their structural interest and documented biological activities. While prior studies have addressed the parent isogermafurenolide through...

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Suresh et al. (2025) studied this question.

synapsesocial.com/papers/6980fdc7c1c9540dea80f6bdhttps://doi.org/10.1039/d6ob00001k
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enantiospecific Syntheses of Bicyclic Fragrance Molecules From Verbenone: Enhancing Odour Profiles and Stability2025 · 2 citations
  2. 2Bioinspired Total Synthesis of Bolivianine: A Diels– Alder/Intramolecular Hetero-Diels–Alder Cascade Approach2013 · 109 citations
  3. 3The use of 4,4-disubstituted nopinones for natural-product synthesis. Synthesis of elemanoid sesquiterpenes1991 · 36 citations
  4. 4Sesquiterpenes from the Medicinal Plants of Africa2013 · 45 citations
  5. 5Chemodivergent Metathesis of Dienynes Catalyzed by Ruthenium–Indenylidene Complexes: An Experimental and Computational Study2009 · 69 citations